TCO-PEG-TCO (MW 5000)
TCO-PEG-TCO (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG-TCO (MW 5000) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Product Specifications
UNSPSC
12352211
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tco-peg-tco-mw-5000.html
Purity
97.12
Solubility
10 mM in DMSO
Smiles
O=C(NCCOCCNC(OC1CC/C=C\CCC1)=O)OC2CC/C=C\CCC2.[MW5000].[n]
Molecular Weight
5000 (Average)
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
365143 200 µL
SPA (Surfactant Associated Protein A, PRL, SFTPA, PSAP, PSPA, SFTP, SFTPA1, COLEC4, PSP-A, SFTP1, SFTPA1B, SP-A1, Collectin-4, Alveolar proteinosis protein, 35kD pulmonary surfactant-associated protein)
Sign In for Pricing
View Details MBS7031472-01 0.02 mg
Recombinant Danio rerio Transmembrane protein 136 (tmem136)
Sign In for Pricing
View Details MBS7031472-02 0.1 mg
Recombinant Danio rerio Transmembrane protein 136 (tmem136)
Sign In for Pricing
View Details MBS7031472-03 5x 0.1 mg
Recombinant Danio rerio Transmembrane protein 136 (tmem136)
Sign In for Pricing
View Details