STL127705
Product Specifications
CAS Number
1326852-06-5
Target
Apoptosis, DNA-PK
Related Pathways
DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling, Apoptosis
Purity
0.9981
Bioactivity
STL127705 (Compound L) is a potent inhibitor of the Ku 70/80 heterodimer protein, disrupting Ku70/80-DNA interaction with an IC50 of 3.5 μM, and inhibiting Ku-dependent DNA-PKCS kinase activation with an IC50 of 2.5 μM.
Smiles
COc1ccc(CCNc2ncc3c(n2)[nH]c(=O)n(-c2cccc(F)c2)c3=O)cc1OC
Molecular Formula
C22H20FN5O4
Molecular Weight
437.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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