Autophinib
Product Specifications
UNSPSC Description
Autophinib is a potent, selective autophagy inhibitor with IC50s of 90 nM and 40 nM for starvation- and Rapamycin-induced autophagy, respectively. Autophinib is also an ATP competitive Vacuolar Protein Sorting 34 (VPS34) inhibitor with an IC50 of 19 nM. Autophinib inhibits autophagy induced by starvation or Rapamycin by targeting VPS34[1].
Target Antigen
Autophagy; PI3K
Type
Reference compound
Related Pathways
Autophagy;PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Autophinib.html
Purity
99.95
Solubility
DMSO : 6.67 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CC1=CC(NC2=NC(OC3=CC=C([N+]([O-])=O)C=C3)=NC(Cl)=C2)=NN1
Molecular Weight
346.73
References & Citations
[1]Robke L, et al. Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34. Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8153-8157.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101920/Autophinib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101920/Autophinib-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1644443-47-9
Available Sizes
Curated Selection
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