Aurora kinase inhibitor-3

Aurora kinase inhibitor-3 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50 of >10 μM. Aurora kinase inhibitor-3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket[1].

Product Specifications

CAS Number

[879127-16-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aurora Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/aurora-kinase-inhibitor-3.html

Purity

99.05

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1CC1)NC2=CC=CC(NC3=NC=CC(NC4=CC=CC(C(F)(F)F)=C4)=N3)=C2

Molecular Formula

C21H18F3N5O

Molecular Weight

413.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Tari LW, et al. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinitydisubstituted pyrimidine inhibitors. Bioorg Med Chem Lett. 2007 Feb 1;17 (3) :688-91.