Levosulpiride

Levosulpiride (RV-12309) is the (S) -enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic agent of the benzamide class.

Product Specifications

CAS Number

[23672-07-3]

Product Name Alternative

RV-12309; S- (-) -Sulpiride

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Levosulpiride.html

Purity

99.87

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NC[C@H]1N(CC)CCC1)C2=CC(S(=O)(N)=O)=CC=C2OC

Molecular Formula

C15H23N3O4S

Molecular Weight

341.43

References & Citations

[1]Arif ST, et al., Enhanced Antidepressant Activity of Nanostructured Lipid Carriers Containing Levosulpiride in Behavioral Despair Tests in Mice. Pharmaceuticals (Basel) . 2023 Aug 29;16 (9) :1220.|[2]Akrab SNA, et al., The role of mosapride and levosulpiride in gut function and glycemic control in diabetic rats. Arab J Gastroenterol. 2023 May;24 (2) :109-116.|[3]Tonini M, et al., 5-HT4 receptors contribute to the motor stimulating effect of levosulpiride in the guinea-pig gastrointestinal tract. Dig Liver Dis. 2003 Apr;35 (4) :244-50.