Tropifexor
Tropifexor (LJN452) is a highly potent agonist of FXR with an EC50 of 0.2 nM[1].
Product Specifications
CAS Number
[1383816-29-2]
Product Name Alternative
LJN452
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
Autophagy; FXR
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Tropifexor.html
Purity
99.35
Solubility
DMSO : ≥ 80.66 mg/mL
Smiles
FC(F)(F)OC(C=CC=C1)=C1C2=NOC(C3CC3)=C2CO[C@@H]4C[C@H]5N(C6=NC7=C(F)C=C(C(O)=O)C=C7S6)[C@H](CC5)C4
Molecular Formula
C29H25F4N3O5S
Molecular Weight
603.58
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Tully DC, et al. Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH) . J Med Chem. 2017 Dec 8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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