BQR-695
BQR-695 is a PI4KIIIβ inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.
Product Specifications
CAS Number
1513879-21-4
Product Name Alternative
NVP-BQR695
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Parasite; PI4K
Type
Reference compound
Related Pathways
Anti-infection; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/BQR-695.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
COC(C(OC)=C1)=CC=C1C2=CC3=NC(NCC(NC)=O)=CN=C3C=C2
Molecular Formula
C19H20N4O3
Molecular Weight
352.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Fowler ML, et al. Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11. Protein Sci. 2016 Apr;25 (4) :826-39.|[2]McNamara CW, et al. Targeting Plasmodium PI (4) K to eliminate malaria. Nature. 2013 Dec 12;504 (7479) :248-253.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI4KIIIβ; Plasmodium
Available Sizes
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