BQR-695

BQR-695 is a PI4KIIIβ inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.

Product Specifications

CAS Number

[1513879-21-4]

Product Name Alternative

NVP-BQR695

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Parasite; PI4K

Type

Reference compound

Related Pathways

Anti-infection; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/BQR-695.html

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

COC(C(OC)=C1)=CC=C1C2=CC3=NC(NCC(NC)=O)=CN=C3C=C2

Molecular Formula

C19H20N4O3

Molecular Weight

352.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Fowler ML, et al. Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11. Protein Sci. 2016 Apr;25 (4) :826-39.|[2]McNamara CW, et al. Targeting Plasmodium PI (4) K to eliminate malaria. Nature. 2013 Dec 12;504 (7479) :248-253.