What is the catalog number for Acolbifene?

The catalog number for Acolbifene is HY-16023A.

What sizes are available for Acolbifene?

Acolbifene is available in the following size(s): 1 mg, 5 mg, 10 mM - 1 mL, 10 mg.

How many pack sizes does Acolbifene come in?

Acolbifene is available in 4 different pack sizes.

Is Acolbifene in stock?

Acolbifene is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Acolbifene?

Acolbifene is manufactured by QuantiMol.

What is the estimated delivery time for Acolbifene?

Estimated delivery time for Acolbifene is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Acolbifene?

The safety data sheet for Acolbifene is available here: http://file.medchemexpress.com/batch_PDF/HY-16023A/Acolbifene-SDS-MedChemExpress.pdf.

Acolbifene

Acolbifene (EM-652), the active metabolite of EM800, is an orally active pure antiestrogen and selective estrogen receptor antagonist. Acolbifene (EM-652) inhibits estradiol (E2) -induced transcriptional activity of ERα (IC50 = 2 nM) and ERβ (IC50 = 0.4 nM) . Acolbifene (EM-652) possesses potent and pure anticarcinogenic properties[1][2][3][4][5].

Product Specifications

CAS Number

182167-02-8

Product Name Alternative

EM-652; SCH 57068

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Acolbifene.html

Purity

99.52

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=CC=C2C(C)=C(C3=CC=C(O)C=C3)[C@H](C4=CC=C(OCCN5CCCCC5)C=C4)OC2=C1

Molecular Formula

C29H31NO4

Molecular Weight

457.56

References & Citations

[1]Wang T, et al. Recent advances in selective estrogen receptor modulators for breast cancer. Mini Rev Med Chem. 2009 Sep;9 (10) :1191-201.|[2]Christian Lemieux, et al. The selective estrogen receptor modulator acolbifene reduces cholesterolemia independently of its anorectic action in control and cholesterol-fed rats. J Nutr. 2005 Sep;135 (9) :2225-9.|[3]A Tremblay, et al. EM-800, a novel antiestrogen, acts as a pure antagonist of the transcriptional functions of estrogen receptors alpha and beta. Endocrinology. 1998 Jan;139 (1) :111-8.|[4]Sylvain Gauthier, et al. Synthesis and structure-activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution. J Enzyme Inhib Med Chem. 2005 Apr;20 (2) :165-77.|[5]F Labrie, et al. EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium. J Steroid Biochem Mol Biol. Apr-Jun 1999;69 (1-6) :51-84.