Hydroxy-PP
Hydroxy-PP is a potent carbonyl reductase 1 (CBR1) inhibitor with an IC50 value of 0.78 μM. Hydroxy-PP also potently inhibits the cytoplasmic tyrosine kinase Fyn with an IC50 value of 5 nM[1].
Product Specifications
CAS Number
[833481-60-0]
UNSPSC
12352005
Target
Carbonyl Reductase; Src
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hydroxy-pp.html
Purity
99.66
Solubility
DMSO : ≥ 110 mg/mL
Smiles
OC1=CC=CC(C2=NN(C(C)(C)C)C3=C2C(N)=NC=N3)=C1
Molecular Formula
C15H17N5O
Molecular Weight
283.33
References & Citations
[1]Tanaka M, et al. An unbiased cell morphology-based screen for new, biologically active small molecules. PLoS Biol. 2005 May;3 (5) :e128.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBR1
Available Sizes
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