L-Theanine

L-Theanine (L-Glutamic Acid γ-ethyl amide) is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective, anticancer and anti-oxidative activities. L-Theanine can pass through the blood–brain barrier and is orally active[1][2][3].

Product Specifications

CAS Number

[3081-61-6]

Product Name Alternative

L-Glutamic Acid γ-ethyl amide; Nγ-Ethyl-L-glutamine

UNSPSC

12352211

Hazard Statement

H317

Target

Apoptosis; Endogenous Metabolite; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-theanine.html

Concentration

10mM

Purity

99.67

Solubility

H2O : 150 mg/mL (ultrasonic)

Smiles

OC([C@@H](N)CCC(NCC)=O)=O

Molecular Formula

C7H14N2O3

Molecular Weight

174.20

Precautions

H317

References & Citations

[1]Vuong QV, et al. L-Theanine: properties, synthesis and isolation from tea. J Sci Food Agric. 2011 Aug 30;91 (11) :1931-9.|[2]Kimura K, et al. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74 (1) :39-45.|[3]Takeshima M, et al. l-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes. J Clin Biochem Nutr. 2016 Sep;59 (2) :93-99.|[4]Zhang R, et al. L-Theanine inhibits melanoma cell growth and migration via regulating expression of the clock gene BMAL1. Eur J Nutr. 2022 Mar;61 (2) :763-777.|[5]Ben P, et al. Protective Effect of L-Theanine on Cadmium-Induced Apoptosis in PC12 Cells by Inhibiting the Mitochondria-Mediated Pathway. Neurochem Res. 2015 Aug;40 (8) :1661-70.