Adaphostin
Product Specifications
UNSPSC Description
Adaphostin (NSC 680410), the adamantyl ester of AG957, is a potent p210bcr/abl inhibitor (IC50=14 μM). Adaphostin induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 ranging from 17 to 216 nM). Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Adaphostin increased the level of reactive oxygen species (ROS) within CLL B cells[1][2][3].
Target Antigen
Apoptosis; Bcr-Abl
Type
Reference compound
Related Pathways
Apoptosis;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/adaphostin.html
Purity
99.02
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C(C=C1)=CC=C1NCC(C=C2O)=C(C=C2)O)OC3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3
Molecular Weight
393.48
References & Citations
[1]Avramis IA, et al. In vitro and in vivo evaluations of the tyrosine kinase inhibitor NSC 680410 against human leukemia and glioblastoma cell lines. Cancer Chemother Pharmacol. 2002;50(6):479-489. |[2]Orsolic N, et al. Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Cancer Sci. 2006;97(9):952-960. |[3]Chandra J, et al. Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells. Blood. 2003;102(13):4512-4519. |[4]Svingen PA, et al. Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro. Clin Cancer Res. 2000;6(1):237-249.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103275/Adaphostin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103275/Adaphostin-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
241127-58-2
Available Sizes
Curated Selection
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