JNJ-63576253

JNJ-63576253 (TRC-253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC) [1].

Product Specifications

CAS Number

[2110428-64-1]

Product Name Alternative

TRC-253

UNSPSC

12352005

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jnj-63576253-hydrochloride.html

Purity

99.22

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

[H]Cl.O=C(N(C(N1C2=CC=C(N=C2)OC3CCNCC3)=S)C(C=C4C(F)(F)F)=CN=C4C#N)C51CCC5

Molecular Formula

C23H22ClF3N6O2S

Molecular Weight

538.97

References & Citations

[1]Zhang Z, et, al. Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC) . J Med Chem. 2021 Jan 28;64 (2) :909-924.