Ochratoxin B

Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788) . Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos[1][2][3][4][5][6].

Product Specifications

CAS Number

[4825-86-9]

UNSPSC

12352005

Hazard Statement

H225, H302+H312+H332, H319

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ochratoxin-b.html

Purity

99.90

Solubility

DMSO : 15 mg/mL (ultrasonic; warming)

Smiles

O=C1O[C@H](CC2=C1C(O)=C(C=C2)C(N[C@@H](CC3=CC=CC=C3)C(O)=O)=O)C

Molecular Formula

C20H19NO6

Molecular Weight

369.37

Precautions

H225, H302+H312+H332, H319

References & Citations

[1]Knasmüller S, et al. Structurally related mycotoxins ochratoxin A, ochratoxin B, and citrinin differ in their genotoxic activities and in their mode of action in human-derived liver (HepG2) cells: implications for risk assessment. Nutr Cancer. 2004;50 (2) :190-7. |[2]O'Brien E, et al. Investigation of the teratogenic potential of ochratoxin A and B using the FETAX system. Birth Defects Res B Dev Reprod Toxicol. 2005 Oct;74 (5) :417-23.|[3]Dietrich DR, et al. Species- and sex-specific renal cytotoxicity of ochratoxin A and B in vitro. Exp Toxicol Pathol. 2001 Jun;53 (2-3) :215-25. |[4]Csenki Z, et al. The individual and combined effects of ochratoxin A with citrinin and their metabolites (ochratoxin B, ochratoxin C, and dihydrocitrinone) on 2D/3D cell cultures, and zebrafish embryo models. Food Chem Toxicol. 2021 Dec;158:112674.|[5]Mally A, et al. Biotransformation and nephrotoxicity of ochratoxin B in rats. Toxicol Appl Pharmacol. 2005 Aug 1;206 (1) :43-53.|[6]Størmer FC, et al. Metabolism of ochratoxin B and its possible effects upon the metabolism and toxicity of ochratoxin A in rats. Appl Environ Microbiol. 1985 May;49 (5) :1108-12.