6RK73
Product Specifications
UNSPSC Description
6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer[1].
Target Antigen
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/6rk73.html
Smiles
O=C([C@@H]1CN(C#N)CC1)NC2=NC=C(N3CCOCC3)S2
Molecular Weight
307.37
References & Citations
[1]Liu S, et al. Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis. Clin Cancer Res. 2019 Dec 19. pii: clincanres.1373.2019.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-133118/6RK73-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-133118/6RK73-SDS-MedChemExpress.pdf
CAS Number
1895050-66-4
Available Sizes
Curated Selection
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