6RK73
6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 µM) . 6RK73 specifically inhibit UCHL1 activity in breast cancer[1].
Product Specifications
CAS Number
[1895050-66-4]
UNSPSC
12352005
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/6rk73.html
Concentration
10mM
Purity
98.41
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1CN(C#N)CC1)NC2=NC=C(N3CCOCC3)S2
Molecular Formula
C13H17N5O2S
Molecular Weight
307.37
References & Citations
[1]Liu S, et al. Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis. Clin Cancer Res. 2019 Dec 19. pii: clincanres.1373.2019.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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