Setiptiline (maleate)

Setiptiline maleate (MO-8282 maleate) is a serotonin receptor antagonist. Setiptiline maleate is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA) . Setiptiline maleate acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine[1][2][3][4].

Product Specifications

CAS Number

[85650-57-3]

Product Name Alternative

MO-8282

UNSPSC

12352005

Hazard Statement

H302-H312-H317-H332-H334

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/setiptiline-maleate.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1CC(C(C=CC=C2)=C2C3)=C(CC1)C4=C3C=CC=C4.O=C(O)/C=C\C(O)=O

Molecular Formula

C23H23NO4

Molecular Weight

377.43

Precautions

P261-P264-P270-P271-P272-P280-P284-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Yamada K, Furukawa T. [Behavioral effects of a new antidepressant, setiptiline]. Nihon Yakurigaku Zasshi. 1991 Jan;97 (1) :31-9.|[2]Kamimura M, Aoba A, Yamaguchi N et al. The effect of age on plasma level of setiptiline maleate in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Oct;18 (6) :1015-26.|[3]Kuniyoshi M, Nakamura J, Miura C, Inanaga K. Effectiveness of concomitant setiptiline maleate (Tecipul) on negative symptoms of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Mar;18 (2) :339-46.|[4]Niho T, Ito C, Shibutani Y, Hashizume H, Yamaguchi K. [Pharmacological properties of MO-8282, a novel antidepressant]. Nihon Yakurigaku Zasshi. 1986 Oct;88 (4) :309-20.