STF-31
STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC50 of 1 μM. STF-31 is also a NAMPT inhibitor. STF-31 inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells[1][2].
Product Specifications
CAS Number
724741-75-7
UNSPSC
12352005
Hazard Statement
H302
Target
Autophagy; GLUT
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/STF-31.html
Purity
99.79
Solubility
DMSO : ≥ 34 mg/mL
Smiles
O=C(NC1=CC=CN=C1)C2=CC=C(CNS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2
Molecular Formula
C23H25N3O3S
Molecular Weight
423.53
Precautions
H302
References & Citations
[1]Chan DA, et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med. 2011 Aug 3;3 (94) :94ra70.|[2]Dedda CD, et al. Pharmacological Targeting of GLUT1 to Control Autoreactive T Cell Responses. International Journal of Molecular Sciences. 2019 Oct 8; 20 (19) :4962.|[3]Wang L, et al. Glucose transporter 1 critically controls microglial activation through facilitating glycolysis. Molecular Neurodegeneration, 2019 Jan 11; 14 (1) :2.|[4]Morioka S, et, al. Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. Nature. 2018 Nov;563 (7733) :714-718.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GLUT1
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1376599-01 0.02 mg (E-Coli)
Recombinant Polaromonas sp. Bifunctional protein FolD (folD)
Sign In for Pricing
View Details MBS1376599-02 0.02 mg (Yeast)
Recombinant Polaromonas sp. Bifunctional protein FolD (folD)
Sign In for Pricing
View Details MBS1376599-03 0.1 mg (E-Coli)
Recombinant Polaromonas sp. Bifunctional protein FolD (folD)
Sign In for Pricing
View Details MBS1376599-04 0.1 mg (Yeast)
Recombinant Polaromonas sp. Bifunctional protein FolD (folD)
Sign In for Pricing
View Details MBS1376599-05 0.02 mg (Baculovirus)
Recombinant Polaromonas sp. Bifunctional protein FolD (folD)
Sign In for Pricing
View Details MBS1376599-06 0.02 mg (Mammalian-Cell)
Recombinant Polaromonas sp. Bifunctional protein FolD (folD)
Sign In for Pricing
View Details