AMG9810
AMG9810 is a selective and competitive vanilloid receptor 1 (TRPV1) antagonist with IC50 values of 24.5 and 85.6 nM for human and rat TRPV1, repectively.
Product Specifications
CAS Number
545395-94-6
UNSPSC
12352005
Hazard Statement
H302, H413
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/AMG9810.html
Purity
99.48
Solubility
DMSO : ≥ 33 mg/mL
Smiles
O=C(NC1=CC=C(OCCO2)C2=C1)/C=C/C3=CC=C(C(C)(C)C)C=C3
Molecular Formula
C21H23NO3
Molecular Weight
337.41
Precautions
H302, H413
References & Citations
[1]Gavva NR, et al. AMG9810 [ (E) -3- (4-t-butylphenyl) -N- (2,3-dihydrobenzo[b][1,4] dioxin-6-yl) acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther. 2005 Apr;313 (1) :474-84.|[2]Li S, et al. TRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling. Carcinogenesis. 2011 May;32 (5) :779-85.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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