AMG9810

AMG9810 is a selective and competitive vanilloid receptor 1 (TRPV1) antagonist with IC50 values of 24.5 and 85.6 nM for human and rat TRPV1, repectively.

Product Specifications

CAS Number

[545395-94-6]

UNSPSC

12352005

Hazard Statement

H302, H413

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/AMG9810.html

Purity

99.48

Solubility

DMSO : ≥ 33 mg/mL

Smiles

O=C(NC1=CC=C(OCCO2)C2=C1)/C=C/C3=CC=C(C(C)(C)C)C=C3

Molecular Formula

C21H23NO3

Molecular Weight

337.41

Precautions

H302, H413

References & Citations

[1]Gavva NR, et al. AMG9810 [ (E) -3- (4-t-butylphenyl) -N- (2,3-dihydrobenzo[b][1,4] dioxin-6-yl) acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther. 2005 Apr;313 (1) :474-84.|[2]Li S, et al. TRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling. Carcinogenesis. 2011 May;32 (5) :779-85.