H3B-120
H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1.5 μM and a Ki of 1.4 μM. H3B-120 has anti-cancer activity[1].
Product Specifications
CAS Number
[2194903-42-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Carbamoyl Phosphate Synthetase (CPS) ; Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/h3b-120.html
Purity
98.36
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(N1CCC(C(NC2=NC(C)=CS2)=O)CC1)N(C)CC3=CC=CC=C3
Molecular Formula
C19H24N4O2S
Molecular Weight
372.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Yao S, et al. Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket. Cell Chem Biol. 2020 Mar 19;27 (3) :259-268.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CPS I
Available Sizes
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