SGD-1882
SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.
Product Specifications
CAS Number
1222490-34-7
Product Name Alternative
PBD dimer
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SGD-1882.html
Purity
98.45
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(OC)=C(OCCCOC(C=C(N=C[C@@]2([H])N(C=C(C3=CC=C(N)C=C3)C2)C4=O)C4=C5)=C5OC)C=C1N=C6)N7[C@@]6([H])CC(C8=CC=C(OC)C=C8)=C7
Molecular Formula
C42H39N5O7
Molecular Weight
725.79
Precautions
H302, H315, H319, H335
References & Citations
[1]Eunhee G. Kim, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics. Biomol Ther (Seoul) . 2015 Nov; 23 (6) : 493-509.|[2]Dowdy Jackson, et al. Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug Conjugates. Pharm Res. 2015; 32 (11) : 3458-3469.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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