SGD-1882
SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.
Product Specifications
CAS Number
1222490-34-7
Product Name Alternative
PBD dimer
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SGD-1882.html
Purity
98.45
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(OC)=C(OCCCOC(C=C(N=C[C@@]2([H])N(C=C(C3=CC=C(N)C=C3)C2)C4=O)C4=C5)=C5OC)C=C1N=C6)N7[C@@]6([H])CC(C8=CC=C(OC)C=C8)=C7
Molecular Formula
C42H39N5O7
Molecular Weight
725.79
Precautions
H302, H315, H319, H335
References & Citations
[1]Eunhee G. Kim, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics. Biomol Ther (Seoul) . 2015 Nov; 23 (6) : 493-509.|[2]Dowdy Jackson, et al. Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug Conjugates. Pharm Res. 2015; 32 (11) : 3458-3469.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LC424467 20 µg
Leukotriene A4 hydrolase (LTA4H) (NM_000895) Human Over-expression Lysate
Sign In for Pricing
View Details 
![TIMP3 Recombinant Rabbit Monoclonal Antibody [PSH04-41]](https://cdn.genprice.uk/products/992/68dd1c8d061270361ea81f09/imageurl/ha722126.webp)
HA722126 100 µL
TIMP3 Recombinant Rabbit Monoclonal Antibody [PSH04-41]
Sign In for Pricing
View Details 
E-CL-H1231-01 24 Tests
Human MAP-2 (Microtubule Associated Protein 2) CLIA Kit
Sign In for Pricing
View Details