SGD-1882

SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

Product Specifications

CAS Number

[1222490-34-7]

Product Name Alternative

PBD dimer

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SGD-1882.html

Purity

98.45

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(OC)=C(OCCCOC(C=C(N=C[C@@]2([H])N(C=C(C3=CC=C(N)C=C3)C2)C4=O)C4=C5)=C5OC)C=C1N=C6)N7[C@@]6([H])CC(C8=CC=C(OC)C=C8)=C7

Molecular Formula

C42H39N5O7

Molecular Weight

725.79

Precautions

H302, H315, H319, H335

References & Citations

[1]Eunhee G. Kim, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics. Biomol Ther (Seoul) . 2015 Nov; 23 (6) : 493-509.|[2]Dowdy Jackson, et al. Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug Conjugates. Pharm Res. 2015; 32 (11) : 3458-3469.