DNDI-6174

DNDI-6174 is a cytochrome bc1 complex inhibitor with potent in vitro activity against a variety of Leishmania species. DNDI-6174 can reduce parasite burden in animal models of infection[1].

Product Specifications

CAS Number

[2868298-43-3]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dndi-6174.html

Purity

97.28

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=CC=C(C2=C(C)NC3=NC(N)=NC(C)=C32)C4=C1OCO4

Molecular Formula

C16H13N5O2

Molecular Weight

307.31

References & Citations

[1]Stéphanie Braillard, et al. DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1. Sci Transl Med. 2023 Dec 13;15 (726) :eadh9902.