4′-Thiouridine

4′-Thiouridine (1- (4-Thio-beta-D-ribofuranosyl) uracil) is a thio analog of thymidine. 4′-Thiouridine can be used to synthesize 4'-thionucleosides with antiviral and anticancer activities. 4′-Thiouridine can be used for RNA-sequencing[1][2][3].

Product Specifications

CAS Number

[6741-73-7]

Product Name Alternative

1- (4-Thio-beta-D-ribofuranosyl) uracil

UNSPSC

12352005

Hazard Statement

H302

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/4-thiouridine.html

Purity

98.68

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N([C@@H]1S[C@H](CO)[C@@H](O)[C@H]1O)C=C2)NC2=O

Molecular Formula

C9H12N2O5S

Molecular Weight

260.27

Precautions

H302

References & Citations

[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.|[2]Benckendorff CMM, et al., Preparation of a 4'-Thiouridine Building-Block for Solid-Phase Oligonucleotide Synthesis. Curr Protoc. 2023 Sep;3 (9) :e878.|[3]Garibaldi A, et al., Isolation of Newly Transcribed RNA Using the Metabolic Label 4-Thiouridine. Methods Mol Biol. 2017;1648:169-176.