4′-Thiouridine
4′-Thiouridine (1- (4-Thio-beta-D-ribofuranosyl) uracil) is a thio analog of thymidine. 4′-Thiouridine can be used to synthesize 4'-thionucleosides with antiviral and anticancer activities. 4′-Thiouridine can be used for RNA-sequencing[1][2][3].
Product Specifications
CAS Number
6741-73-7
Product Name Alternative
1- (4-Thio-beta-D-ribofuranosyl) uracil
UNSPSC
12352005
Hazard Statement
H302
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/4-thiouridine.html
Purity
98.68
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N([C@@H]1S[C@H](CO)[C@@H](O)[C@H]1O)C=C2)NC2=O
Molecular Formula
C9H12N2O5S
Molecular Weight
260.27
Precautions
H302
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.|[2]Benckendorff CMM, et al., Preparation of a 4'-Thiouridine Building-Block for Solid-Phase Oligonucleotide Synthesis. Curr Protoc. 2023 Sep;3 (9) :e878.|[3]Garibaldi A, et al., Isolation of Newly Transcribed RNA Using the Metabolic Label 4-Thiouridine. Methods Mol Biol. 2017;1648:169-176.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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