Calycosin

Calycosin is a compound that can be isolated from Radix Astragali. Calycosin has strong antioxidant, anti-inflammatory and apoptosis-modulating effects. Calycosin can be used for the research of ovarian cancer and breast cancer[1][2].

Product Specifications

CAS Number

[20575-57-9]

Product Name Alternative

Cyclosin

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Calycosin.html

Purity

99.96

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1C(C2=CC=C(OC)C(O)=C2)=COC3=CC(O)=CC=C13

Molecular Formula

C16H12O5

Molecular Weight

284.26

Precautions

H301

References & Citations

[1]Zhou Y, et al. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Tumour Biol. 2015 Feb 12.|[2]Chen J, et al. Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo. Cancer Lett. 2011 Sep 28;308 (2) :144-51.|[3]Guo C, et al. Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats. J Ethnopharmacol. 2012 Dec 18;144 (3) :768-74.