SIAIS178
Product Specifications
CAS Number
2376047-73-1
Target
PROTACs, Ligand for E3 Ligase, Bcr-Abl
Related Pathways
Angiogenesis, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, PROTAC
Purity
0.9807
Bioactivity
SIAIS178 is a selective PROTAC degrader targeting BCR-ABL with an IC50 of 24 nM. It degrades BCR-ABL protein by recruiting the VHL E3 ubiquitin ligase, inhibiting leukaemia cell growth in vitro and causing regression of K562 xenograft tumours.
Smiles
C([C@@H](NC(CCCCCCC(=O)N1CCN(CC1)C=2C=C(NC=3SC(C(NC4=C(C)C=CC=C4Cl)=O)=CN3)N=C(C)N2)=O)[C@](C)(C)C)(=O)N5[C@H](C(NCC6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@@H](O)C5
Molecular Formula
C50H62ClN11O6S2
Molecular Weight
1012.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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