α-Casein (90-95) (TFA)

α-Casein (90-95) TFA is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) TFA inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC50= 0.1 μM. α-Casein (90-95) TFA inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC50 of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) TFA activates Gi-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) TFA can be used in the study of the mechanisms of allergic diseases and prostate cancer[1][2][3].

Product Specifications

UNSPSC

12352209

Target

Biochemical Assay Reagents; Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-casein-90-95-tfa.html

Purity

99.58

Solubility

H2O : ≥ 100 mg/mL

Smiles

OC(C(F)(F)F)=O.O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N

Molecular Formula

C40H58F3N9O11

Molecular Weight

897.94

References & Citations

[1]Chruścińska E, et al. Binding ability of Cu2+ ions by opiate-like fragments of bovine casein. J Inorg Biochem. 1997 Apr;66 (1) :19-22.|[2]Stępnik M, et al. The influence of bovine casein-derived exorphins on mast cells in rodents[J]. Revue française d'allergologie et d'immunologie clinique, 2002, 42 (5) : 447-453.|[3]Kampa M, et al. Opioid alkaloids and casomorphin peptides decrease the proliferation of prostatic cancer cell lines (LNCaP, PC3 and DU145) through a partial interaction with opioid receptors. Eur J Pharmacol. 1997 Sep 24;335 (2-3) :255-65.