α-Casein (90-95) (TFA)
α-Casein (90-95) TFA is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) TFA inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC50= 0.1 μM. α-Casein (90-95) TFA inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC50 of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) TFA activates Gi-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) TFA can be used in the study of the mechanisms of allergic diseases and prostate cancer[1][2][3].
Product Specifications
UNSPSC
12352209
Target
Biochemical Assay Reagents; Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/α-casein-90-95-tfa.html
Purity
99.58
Solubility
H2O : ≥ 100 mg/mL
Smiles
OC(C(F)(F)F)=O.O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N
Molecular Formula
C40H58F3N9O11
Molecular Weight
897.94
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1793A/α-Casein-90-95-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1793A/α-Casein-90-95-TFA-SDS-MedChemExpress.pdf
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
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