Paradol
Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX) -2 active site.
Product Specifications
CAS Number
27113-22-0
Product Name Alternative
[6]-Gingerone; [6]-Paradol
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Paradol.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : ≥ 140 mg/mL
Smiles
COC1=C(O)C=CC(CCC(CCCCCCC)=O)=C1
Molecular Formula
C17H26O3
Molecular Weight
278.39
Precautions
H302, H315, H319, H335
References & Citations
[1]van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale) . Fitoterapia. 2011 Jan;82 (1) :38-43.|[2]Keum YS, et al. Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells. Cancer Lett. 2002 Mar 8;177 (1) :41-7.|[3]Gaire BP, et al. Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia. PLoS One. 2015 Mar 19;10 (3) :e0120203.|[4]Setoguchi S, et al. Pharmacokinetics of Paradol Analogues Orally Administered to Rats. J Agric Food Chem. 2016 Mar 9;64 (9) :1932-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2
Available Sizes
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