Paradol

Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX) -2 active site.

Product Specifications

CAS Number

[27113-22-0]

Product Name Alternative

[6]-Gingerone; [6]-Paradol

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Paradol.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : ≥ 140 mg/mL

Smiles

COC1=C(O)C=CC(CCC(CCCCCCC)=O)=C1

Molecular Formula

C17H26O3

Molecular Weight

278.39

Precautions

H302, H315, H319, H335

References & Citations

[1]van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale) . Fitoterapia. 2011 Jan;82 (1) :38-43.|[2]Keum YS, et al. Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells. Cancer Lett. 2002 Mar 8;177 (1) :41-7.|[3]Gaire BP, et al. Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia. PLoS One. 2015 Mar 19;10 (3) :e0120203.|[4]Setoguchi S, et al. Pharmacokinetics of Paradol Analogues Orally Administered to Rats. J Agric Food Chem. 2016 Mar 9;64 (9) :1932-7.