SB-657510
Product Specifications
CAS Number
474960-44-6
Target
GPCR, Neurotensin Receptor
Related Pathways
GPCR/G Protein, Endocrinology/Hormones
Purity
0.9818
Bioactivity
SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting UII-induced inflammatory mediators, such as adhesion molecules, in human vascular endothelial cells and upregulation of cytokines and tissue factors. SB 657510 has a therapeutic effect on diabetes-related atherosclerotic disease in diabetic mouse models.
Smiles
COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(Cl)c(O[C@@H]2CCN(C)C2)c1
Molecular Formula
C19H22BrClN2O5S
Molecular Weight
505.81
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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