SAR405
Product Specifications
CAS Number
1523406-39-4
Target
PI3K, Autophagy
Related Pathways
Autophagy, PI3K/Akt/mTOR signaling
Purity
0.9979
Bioactivity
SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.
Smiles
C[C@@H]1COCCN1c1cc(=O)n2CC[C@H](N(Cc3cncc(Cl)c3)c2n1)C(F)(F)F
Molecular Formula
C19H21ClF3N5O2
Molecular Weight
443.85
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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