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RU-SKI 43

Product Specifications

CAS Number

1043797-53-0

Target

Hedgehog/Smoothened, Acyltransferase

Related Pathways

GPCR/G Protein, Metabolism, Stem Cells

Purity

0.9985

Bioactivity

RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. It exhibits anticancer activity and is a potential treatment for lung adenocarcinomas. RU-SKI 43 reduces Gli-1 activation through smoothening-independent non-canonical signaling and inhibits Akt and mTOR pathway activity.

Smiles

C(OC1=CC(C)=CC=C1)C2C3=C(CCN2C(CNCC(CC)C)=O)SC=C3

Molecular Formula

C22H30N2O2S

Molecular Weight

386.55

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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