RU-SKI 43
Product Specifications
CAS Number
1043797-53-0
Target
Hedgehog/Smoothened, Acyltransferase
Related Pathways
GPCR/G Protein, Metabolism, Stem Cells
Purity
0.9985
Bioactivity
RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. It exhibits anticancer activity and is a potential treatment for lung adenocarcinomas. RU-SKI 43 reduces Gli-1 activation through smoothening-independent non-canonical signaling and inhibits Akt and mTOR pathway activity.
Smiles
C(OC1=CC(C)=CC=C1)C2C3=C(CCN2C(CNCC(CC)C)=O)SC=C3
Molecular Formula
C22H30N2O2S
Molecular Weight
386.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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