SBE13 (Hydrochloride)

SBE13 Hydrochloride is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 Hydrochloride poorly inhibits Plk2 (IC50>66 μM) or Plk3 (IC50=875 nM) .

Product Specifications

CAS Number

[1052532-15-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Polo-like Kinase (PLK)

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SBE13-Hydrochloride.html

Purity

98.56

Solubility

DMSO : ≥ 100 mg/mL|H2O : 5 mg/mL (ultrasonic)

Smiles

COC1=CC=C(CCNCC2=CC=C(OCC3=CC=C(Cl)N=C3)C(OC)=C2)C=C1OC.[H]Cl

Molecular Formula

C24H28Cl2N2O4

Molecular Weight

479.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Keppner S, et al. Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1. ChemMedChem. 2009 Nov;4 (11) :1806-9.|[2]Keppner S, et al. Fate of primary cells at the G?/S boundary after polo-like kinase 1 inhibition by SBE13. Cell Cycle. 2011 Feb 15;10 (4) :708-20. Epub 2011 Feb 15.|[3]Keppner S, et al. Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle. 2010 Feb 15;9 (4) :761-73. Epub 2010 Feb 16.