SBE13 (Hydrochloride)
Product Specifications
UNSPSC Description
SBE13 Hydrochloride is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 Hydrochloride poorly inhibits Plk2 (IC50>66?μM) or Plk3 (IC50=875?nM).
Target Antigen
Apoptosis; Autophagy; Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Apoptosis;Autophagy;Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SBE13-Hydrochloride.html
Solubility
DMSO : ≥ 100 mg/mL|H2O : 5 mg/mL (ultrasonic)
Smiles
COC1=CC=C(CCNCC2=CC=C(OCC3=CC=C(Cl)N=C3)C(OC)=C2)C=C1OC.[H]Cl
Molecular Weight
479.40
References & Citations
[1]Keppner S, et al. Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1. ChemMedChem. 2009 Nov;4(11):1806-9.|[2]Keppner S, et al. Fate of primary cells at the G?/S boundary after polo-like kinase 1 inhibition by SBE13. Cell Cycle. 2011 Feb 15;10(4):708-20. Epub 2011 Feb 15.|[3]Keppner S, et al. Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle. 2010 Feb 15;9(4):761-73. Epub 2010 Feb 16.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15158/SBE13-Hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15158/SBE13-Hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1052532-15-6
Available Sizes
Curated Selection
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