FLT3/HDAC-IN-1
FLT3/HDAC-IN-1 is a dual inhibitor of FLT3/HDAC, with IC50 values of 30.4, 52.4, and 14.7 nM for FLT3, HDAC1, and HDAC3, respectively. FLT3/HDAC-IN-1 can induce apoptosis in MV-4-11 cells and has anti-proliferative effects on FLT3 mutant-transformed BaF3 cells. FLT3/HDAC-IN-1 is being researched for its potential in treating hard-to-treat solid tumors and hematological malignancies[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; FLT3; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flt3-hdac-in-1.html
Smiles
ClC1=CN=C(N=C1C2=CN=C3N2C=CC=C3)NC4=CN(N=C4)CC5=CC=C(C=C5)C(NNCCC)=O
Molecular Formula
C25H24ClN9O
Molecular Weight
501.97
References & Citations
[1]Saidahmatov A, et al. Discovery of Novel 2-Aminopyridine-Based and 2-Aminopyrimidine-Based Derivatives as Potent CDK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors and Hematological Malignancies. J Med Chem. 2024 Sep 12;67 (17) :15220-15245.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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