Plevitrexed
Product Specifications
CAS Number
153537-73-6
Target
Others, DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Others
Bioactivity
Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is an orally active and effective thymidylate synthase (TS) inhibitor (Ki: 0.44 nM) . Plevitrexed is used for gastric cancer in clinical.
Smiles
O=C1C=2C(=CC(C)=C(CN(CC#C)C3=CC(F)=C(C(N[C@@H](CCC=4NN=NN4)C(O)=O)=O)C=C3)C2)NC(C)=N1
Molecular Formula
C26H25FN8O4
Molecular Weight
532.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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