FT671
Product Specifications
CAS Number
1959551-26-8
Target
DUB
Related Pathways
DNA Damage/DNA Repair|||Ubiquitination|||Cell Cycle/Checkpoint
Purity
0.9976
Bioactivity
FT671 is a non-covalent, selective USP7 inhibitor (IC50=52 nM) that binds to the catalytic domain of USP7 (Kd=7.8 µM) . It disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, and inhibits tumor growth in mice.
Smiles
O=C1C2=C(N(N=C2)C3=CC=C(F)C=C3)N=CN1CC4(O)CCN(C(C[C@@H]([C@H](F)F)N5N=C(F)C=C5)=O)CC4
Molecular Formula
C24H23F4N7O3
Molecular Weight
533.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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