CLIC1 rabbit pAb

Chloride intracellular channel 1 (CLIC1) Homo sapiens Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane Chloride ion channel activity. [provided by RefSeq, Jul 2008],

Product Specifications

Background

Chloride intracellular channel 1 (CLIC1) Homo sapiens Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

UniProt

O00299

Swiss Prot

O00299

Reactivity

Human; Rat; Mouse

Immunogen

Synthetic Peptide of CLIC1 AA range: 166-216

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF

Concentration

1 mg/ml

Dilution

IHC 1:100-200

Molecular Weight

30kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

30kD

Fragment

IgG

Subcellular Location

Nucleus . Nucleus membrane ; Single-pass membrane protein . Cytoplasm . Cell membrane ; Single-pass membrane protein . Mostly in the nucleus including in the nuclear membrane (PubMed:9139710, PubMed:12681486) . Small amount in the cytoplasm and the plasma membrane (PubMed:9139710) . Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (PubMed:11940526, PubMed:11551966, PubMed:14613939) . .

Other Product Names

Chloride intracellular channel protein 1 (Chloride channel ABP; Nuclear chloride ion channel 27; NCC27; Regulatory nuclear chloride ion channel protein; hRNCC)