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Pyrotinib dimaleate

Product Specifications

CAS Number

1397922-61-0

Target

HER, EGFR

Related Pathways

JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis

Purity

0.9952

Bioactivity

Pyrotinib dimaleate is a selective EGFR/HER2 dual inhibitor with IC50 values ​​of 13 and 38 nM, respectively, for the treatment of HER2-positive breast cancer.

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OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\[C@H]1CCCN1C

Molecular Formula

C40H39ClN6O11

Molecular Weight

815.22

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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