ACBI3

ACBI3 (compound 7), a chemical probe, is a PROTAC targeting KRAS. ACBI3 is composed of PROTAC target protein ligand pan-KRAS degrader 1 (HY-162960) (red part), E3 ligase ligand E3 ligase Ligand 43 (HY-401613) (blue part) and PROTAC Linker 1-Bromo-4- (ethynyloxy) butane (HY-169992) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 143 (HY-169995) . ACBI3 achieves in vivo degradation of oncogenic KRAS, resulting in durable pathway modulation and tumor regressions in KRAS mutant xenograft mouse models[1][2][3].

Product Specifications

CAS Number

[2938169-76-5]

UNSPSC

12352005

Target

PROTACs; Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/acbi3.html

Purity

99.47

Solubility

DMSO : 140 mg/mL (ultrasonic)

Smiles

NC(SC1=C2[C@](C3=NC(C4=NC(N5CCCN(CCCCOC(N=N6)=CN6[C@@H](C(C)C)C(N7[C@H](C(N[C@@H](CO)C8=CC=C(C=C8)C9=C(N=CS9)C)=O)C[C@@H](O)C7)=O)C[C@@H]5C)=NC=C4)=NO3)(C)CCC1)=C2C#N

Molecular Formula

C50H62N14O6S2

Molecular Weight

1019.25

References & Citations

[1]Popow J, et al. Targeting cancer with small molecule pan-KRAS degraders[J]. bioRxiv, 2023: 2023.10. 24.563163.|[2]Hamilton G, et al. Development of PROTACS degrading KRAS and SOS1. Oncol Res. 2024 Jul 17;32 (8) :1257-1264.|[3]Cox AD, et al. KRAS takes the road to destruction. Science. 2024 Sep 20;385 (6715) :1274-1275.