ACBI3
Product Specifications
UNSPSC Description
ACBI3 (compound 7) is a PROTAC targeting KRAS. ACBI3 is composed of PROTAC target protein ligand pan-KRAS degrader 1 (HY-162960) (red part), E3 ligase ligand E3 ligase Ligand 43 (HY-401613) (blue part) and PROTAC Linker 1-Bromo-4-(ethynyloxy)butane (HY-169992) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 143 (HY-169995)[1].
Target Antigen
Others; PROTACs
Type
Reference compound
Related Pathways
Others;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/acbi3.html
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
NC(SC1=C2[C@](C3=NC(C4=NC(N5CCCN(CCCCOC(N=N6)=CN6[C@@H](C(C)C)C(N7[C@H](C(N[C@@H](CO)C8=CC=C(C=C8)C9=C(N=CS9)C)=O)C[C@@H](O)C7)=O)C[C@@H]5C)=NC=C4)=NO3)(C)CCC1)=C2C#N
Molecular Weight
1019.25
References & Citations
[1]Popow J, et al. Targeting cancer with small molecule pan-KRAS degraders[J]. bioRxiv, 2023: 2023.10. 24.563163.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157228/ACBI3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157228/ACBI3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2938169-76-5
Available Sizes
Curated Selection
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