Plecanatide acetate

Plecanatide acetate is a agonist of guanylate cyclase-C (GC-C) receptor (EC50 of 190 nM in T84 cells), and shows anti-inflammatory activity in models of murine colitis.

CC(O)=O.[H][C@@]1(CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@]([H])(CSSC[C@]2([H])NC(=O)[C@H](C)NC(=O)C(NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@]([H])(CSSC[C@H](NC(=O)CNC(=O)[C@@]([H])(NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(O)=O)NC1=O)C(C)C)C(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CC(N)=O |@:93|