Neriifolin
Product Specifications
CAS Number
466-07-9
Target
Apoptosis, ATPase, Autophagy, ATG
Related Pathways
Autophagy, Membrane transporter/Ion channel, Apoptosis
Bioactivity
Neriifolin (17β-Neriifolin), a cardiac glycoside extracted from the unripe fruit of Cerbera manghas, is a Na+K+-ATPase inhibitor with anticancer activity that inhibits cell proliferation by suppressing HOXA9-dependent gene expression and inducing apoptosis in the human acute myeloid cell line, THP-1. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells and can be used in prostate cancer research.
Smiles
O[C@@]12[C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@@H](O[C@H]5[C@@H](O)[C@H](OC)[C@@H](O)[C@H](C)O5)CC4)[H])(CC[C@]1(C)[C@H](CC2)C6=CC(=O)OC6)[H])[H]
Molecular Formula
C30H46O8
Molecular Weight
534.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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