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PIM447

Product Specifications

CAS Number

1210608-43-7

Target

Pim, Apoptosis

Related Pathways

Apoptosis, Chromatin/Epigenetic, JAK/STAT signaling

Purity

0.9897

Bioactivity

PIM447 (LGH447) is an oral, selective pan-PIM kinase inhibitor with antitumor and bone-protective effects. It inhibits PIM1, PIM2, and PIM3, induces apoptosis, and decreases the viability, proliferation, and motility of HuH6 and COA67 cells. PIM447 suppresses tumorigenesis in hepatocellular carcinoma and can be used in the study of multiple myeloma.

Smiles

FC1=C(N=C(C(NC=2C(=CC=NC2)[C@@H]3C[C@H](C)C[C@H](N)C3)=O)C=C1)C4=C(F)C=CC=C4F

Molecular Formula

C24H23F3N4O

Molecular Weight

440.46

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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