PIM447
Product Specifications
CAS Number
1210608-43-7
Target
Pim|||Apoptosis
Related Pathways
Apoptosis|||Chromatin/Epigenetic|||JAK/STAT signaling
Purity
0.9897
Bioactivity
PIM447 (LGH447) is an oral, selective pan-PIM kinase inhibitor with antitumor and bone-protective effects. It inhibits PIM1, PIM2, and PIM3, induces apoptosis, and decreases the viability, proliferation, and motility of HuH6 and COA67 cells. PIM447 suppresses tumorigenesis in hepatocellular carcinoma and can be used in the study of multiple myeloma.
Smiles
FC1=C(N=C(C(NC=2C(=CC=NC2)[C@@H]3C[C@H](C)C[C@H](N)C3)=O)C=C1)C4=C(F)C=CC=C4F
Molecular Formula
C24H23F3N4O
Molecular Weight
440.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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