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SLV-2436

SLV-2436 is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8 nM and 5.4 nM, respectively.

Product Specifications

CAS Number

2095704-43-9

Product Name Alternative

SEL201-88; SEL-201

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SLV-2436.html

Purity

98.53

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1C=CC(C2=CC3=C(C=C2)C(N)=NN3)=CN1CC4=CC=CC(Cl)=C4

Molecular Formula

C19H15ClN4O

Molecular Weight

350.80

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhan Y, et al. MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma. J Clin Invest. 2017 Nov 1;127 (11) :4179-4192.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MNK1; MNK2

Available Sizes

Frequently Asked Questions

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