SLV-2436
SLV-2436 is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8 nM and 5.4 nM, respectively.
Product Specifications
CAS Number
2095704-43-9
Product Name Alternative
SEL201-88; SEL-201
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SLV-2436.html
Purity
98.53
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C=CC(C2=CC3=C(C=C2)C(N)=NN3)=CN1CC4=CC=CC(Cl)=C4
Molecular Formula
C19H15ClN4O
Molecular Weight
350.80
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhan Y, et al. MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma. J Clin Invest. 2017 Nov 1;127 (11) :4179-4192.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MNK1; MNK2
Available Sizes
Frequently Asked Questions
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