(S, R, S) -AHPC-Me-C10-Br
(S, R, S) -AHPC-Me-C10-Br is a synthesized E3 ligase ligand-linker conjugate. (S, R, S) -AHPC-Me-C10-Br incorporates a VHL E3 ligase linker and MS432 based on the MEK1/2 inhibitor PD0325901[1].
Product Specifications
CAS Number
[2836297-55-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-r-s-ahpc-me-c10-br.html
Concentration
10mM
Purity
98.02
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(CCCCCCCCCCBr)=O)C(C)(C)C)=O
Molecular Formula
C34H51BrN4O4S
Molecular Weight
691.76
Precautions
H302, H315, H319, H335
References & Citations
[1]Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.J Med Chem. 2019 Dec 12;62 (23) :10897-10911.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
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