(S, R, S) -AHPC-Me-C10-Br
(S, R, S) -AHPC-Me-C10-Br is a synthesized E3 ligase ligand-linker conjugate. (S, R, S) -AHPC-Me-C10-Br incorporates a VHL E3 ligase linker and MS432 based on the MEK1/2 inhibitor PD0325901[1].
Product Specifications
CAS Number
[2836297-55-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-r-s-ahpc-me-c10-br.html
Concentration
10mM
Purity
98.02
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(CCCCCCCCCCBr)=O)C(C)(C)C)=O
Molecular Formula
C34H51BrN4O4S
Molecular Weight
691.76
Precautions
H302, H315, H319, H335
References & Citations
[1]Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.J Med Chem. 2019 Dec 12;62 (23) :10897-10911.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
Explore Other Products
Browse additional items from our catalog
Poly (ethylene glycol) diacrylate (MW 575), MEHQ as inhibitor
Poly (ethylene glycol) diacrylate (MW 575), MEHQ as inhibitor
Poly (ethylene glycol) diacrylate (MW 575), MEHQ as inhibitor
