Palbociclib-d8
Product Specifications
CAS Number
1628752-83-9
Target
CDK
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
Palbociclib-d8 (PD 0332991 D8) is the 2H-labeled form of Palbociclib. Palbociclib is an orally active CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11/16 nM) . Palbociclib has anti-tumor activity and is used in research for estrogen receptor-positive and HER2-negative breast cancer.
Smiles
O=C1N(C=2C(C(C)=C1C(C)=O)=CN=C(NC3=CC=C(C=N3)N4C(C(NC(C4([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])N2)C5CCCC5
Molecular Formula
C24H21D8N7O2
Molecular Weight
455.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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