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Palbociclib-d8

Product Specifications

CAS Number

1628752-83-9

Target

CDK

Related Pathways

Cell Cycle/Checkpoint

Bioactivity

Palbociclib-d8 (PD 0332991 D8) is the 2H-labeled form of Palbociclib. Palbociclib is an orally active CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11/16 nM) . Palbociclib has anti-tumor activity and is used in research for estrogen receptor-positive and HER2-negative breast cancer.

Smiles

O=C1N(C=2C(C(C)=C1C(C)=O)=CN=C(NC3=CC=C(C=N3)N4C(C(NC(C4([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])N2)C5CCCC5

Molecular Formula

C24H21D8N7O2

Molecular Weight

455.58

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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