NPD-1335
Product Specifications
CAS Number
2376326-31-5
Target
Parasite, Others, PDE
Related Pathways
Others, Metabolism, Microbiology/Virology
Bioactivity
NPD1335, a potent inhibitor of Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1), exhibits submicromolar activity against T. brucei parasites and an improved cytotoxicity profile. By elevating intracellular cAMP levels, NPD1335 disrupts the cell cycle, leading to cell death [1].
Smiles
[H][C@]12CC=CC[C@@]1([H])C(=NN(C(C)C)C2=O)c1ccc(OC)c(c1)C#CC(=O)NCc1ccccc1
Molecular Formula
C28H29N3O3
Molecular Weight
455.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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